Using Physiologically Based Pharmacokinetic Modeling for Mechanistic Insight: Cases of Reverse Translation

Observation of a clinical event can spur reflective thinking on its source. In pharmacology, adverse events are examples of observations for which deriving the cause is important. Moving from observation to mechanistic understanding requires the use of tools that explicitly delineate biological systems, mode of action, and disease pathophysiology. By expanding understanding of biological factors that influence these events, such tools may allow scientists to discover triggering processes, and once confirmed, a means of mitigation.